Rabbit Anti-SCAI/FITC Conjugated antibody

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C9orf126; FLJ11758; FLJ36664; MGC120525; MGC120526; MGC120528; NET40; Protein SCAI; SCAI; SCAI_HUMAN; Suppressor of cancer cell invasion; Suppressor of cancer cell invasion protein.

Cat:

SL17260R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human SCAI

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

70kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Function:
Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.

Subunit:
Interacts with DIAPH1 (By similarity). Forms a nuclear ternary complex with MKL1 and SRF.

Subcellular Location:
Membrane. Nucleus. Cytoplasm. Nuclear localization is required for inhibition of MKL1.

Similarity:
Belongs to the SCAI family.

Database links:

Entrez Gene: 286205 Human

Entrez Gene: 64271 Mouse

Entrez Gene: 690538 Rat

SwissProt: Q8N9R8 Human

SwissProt: Q8C8N2 Mouse

Unigene: 59504 Human

Unigene: 204836 Mouse

Unigene: 206053 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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