background:
SCARA5 is a 495 amino acid cell membrane protein. SCARA5 is expressed at high levels in testis, with highest levels specifically found in specific populations of epithelial cells and Sertoli cells. SCARA5 forms a homotrimer single-pass type II membrane complex present on the surface of the plasma membrane. Cells transfected with SCARA5 were able to bind particular gram-positive and gram-negative bacteria, suggesting a possible role for SCARA5 in immunity to infection. It has also been suggested that SCARA5 may be involved in transferrin delivery pathways. Expressed as four isoforms produced by alternative splicing, SCARA5 contains one collagen-like domain and one SRCR domain.
Function:
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
Subunit:
Homotrimer.
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the SCARA5 family.
Contains 1 collagen-like domain.
Contains 1 SRCR domain.
Database links:
Entrez Gene: 286133 Human
Entrez Gene: 71145 Mouse
Omim: 611306 Human
SwissProt: Q6ZMJ2 Human
SwissProt: Q8K299 Mouse
Unigene: 591833 Human
Unigene: 83168 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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