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Rabbit Anti-SCARF1/FITC Conjugated antibody
background:
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Function:
Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth.
Subunit:
Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).
Subcellular Location:
Membrane.
Tissue Specificity:
Endothelial cells.
Similarity:
Contains 6 EGF-like domains.
Database links:
Entrez Gene: 8578 Human
Omim: 607873 Human
SwissProt: Q14162 Human
Unigene: 647430 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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