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Rabbit Anti-Scavenger Receptor BI + BII/FITC Conjugated antibody
background:
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Function:
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
Subcellular Location:
Lysosome; lysosomal membrane; multi-pass membrane protein.
Database links:
Entrez Gene: 949 Human
Entrez Gene: 950 Human
Entrez Gene: 12492 Mouse
Entrez Gene: 20778 Mouse
Entrez Gene: 117106 Rat
Entrez Gene: 25073 Rat
Omim: 601040 Human
Omim: 602257 Human
SwissProt: Q14108 Human
SwissProt: Q8WTV0 Human
SwissProt: O35114 Mouse
SwissProt: Q61009 Mouse
SwissProt: P27615 Rat
SwissProt: P97943 Rat
Unigene: 298813 Human
Unigene: 349656 Human
Unigene: 592984 Human
Unigene: 282242 Mouse
Unigene: 297964 Mouse
Unigene: 399507 Mouse
Unigene: 410528 Mouse
Unigene: 3957 Rat
Unigene: 88169 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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