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Rabbit Anti-SCIN/FITC Conjugated antibody
background:
SCIN (Scinderin) is a Ca(2+) dependent actin filament severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro SCIN also has barbed end capping and nucleating activities in the presence of Ca(2+).
Function:
Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).
Subcellular Location:
Cytoplasmic, cytoskeleton.
Similarity:
Belongs to the villin/gelsolin family.
Contains 6 gelsolin-like repeats.
Database links:
Entrez Gene: 85477 Human
Omim: 613416 Human
SwissProt: Q9Y6U3 Human
SwissProt: D4A2G2 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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