background:
LULL1 is a 470 amino acid endoplasmic reticulum single-pass membrane protein belonging to the TOR1AIP family. LULL1 interacts with torsinA, an essential AAA+ ATPase found in the endoplasmic reticulum (ER) and nuclear envelope (NE) of higher eukaryotes. LULL1 regulates the distribution and activity of torsinA within the ER and NE lumen and reveals functional defects in mutant torsinA, which is responsible for DYT1 dystonia, a neurodevelopmental disease caused by an in-frame deletion (Deltagag) in the gene encoding torsinA. The gene encoding LULL1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
Function:
Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope.
Subunit:
Interacts with TOR1A and TOR1B (ATP-bound).
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane.
Database links:
Entrez Gene: 163590 Human
Entrez Gene: 304881 Rat
Omim: 614513 Human
SwissProt: Q8NFQ8 Human
SwissProt: Q6P752 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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