Rabbit Anti-4HPPD/FITC Conjugated antibody

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HPD; 4 HPPD; 4 hydroxyphenylpyruvate dioxygenase; 4 hydroxyphenylpyruvic acid oxidase; 4HPPD; GLOD3; glyoxalase domain containing 3; HPPDase; PPD.

Cat:

SL17378R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human 4HPPD

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

45kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Function:
HPD participates in the tyrosine catabolic pathway by catalyzing the conversion of 4-hydroxyphenylpyruvate to homogentisate. The mechanism of action of HPD involves a decarboxylation step and an oxidation step, followed by a rearrangement step to form homogentisic acid. Alterations in the structure and activity of HPD are causally related to two different metabolic disorders, the recessively inherited tyrosinemia type III and the dominantly inherited hawkinsinuria.

Subcellular Location:
Cytoplasmic

Database links:

Entrez Gene: 3242 Human

Entrez Gene: 15445 Mouse

Entrez Gene: 29531 Rat

Omim: 609695 Human

SwissProt: P32754 Human

SwissProt: P49429 Mouse

SwissProt: P32755 Rat

Unigene: 2899 Human

Unigene: 439709 Mouse

Unigene: 3664 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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