Rabbit Anti-Homer (1b+1c)/FITC Conjugated antibody

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Homer 1; HOMER; Homer homolog 1; Homer protein homolog 1; Homer1; HOMER1B; HOMER1C; Neuronal immediate early gene; SYN47; Ves 1. HOME1_HUMAN

Cat:

SL17352R-FITC

Species Reactivity：

Human,Rat,(predicted: Mouse,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Homer (1b+1c)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

45kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

Function:
Homer is a neuronal immediate early gene that is enriched at excitatory synapses and selectively binds metabotropic glutamate receptors.

Subunit:
Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2,SHANK1 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization.

Subcellular Location:
Cytoplasmic; Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.

Similarity:
Belongs to the Homer family. Contains 1 WH1 domain.

Database links:

Entrez Gene: 9456 Human

Entrez Gene: 26556 Mouse

Entrez Gene: 29546 Rat

Omim: 604798 Human

SwissProt: Q86YM7 Human

SwissProt: Q9Z2Y3 Mouse

SwissProt: Q9Z214 Rat

Unigene: 591761 Human

Unigene: 37500 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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