background:
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.
Function:
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Subunit:
Binds actin and the Arp2/3 complex.
Subcellular Location:
Cytoplasm, cytoskeleton.
Tissue Specificity:
Expressed in ovary and brain.
Post-translational modifications:
Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.
Similarity:
Belongs to the SCAR/WAVE family.
Contains 1 WH2 domain.
Database links:
Entrez Gene: 10810 Human
Entrez Gene: 245176 Mouse
Omim: 605068 Human
SwissProt: Q9UPY6 Human
SwissProt: Q8VHI6 Mouse
Unigene: 635221 Human
Unigene: 472750 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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