background:
17 beta-HSD13 (17 beta hydroxysteroid dehydrogenase type 13), also designated Short-chain dehydrogenase/reductase 9 (SCDR9), belongs to the 17 beta-HSD family of proteins, which regulate the availability of steroids within various tissues throughout the body. 17 beta-HSD13 is a 300 amino acid secreted protein that is highly expressed in liver and is also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis. The gene encoding 17 beta-HSD13 maps to chromosome 4, which houses nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Function:
Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.
Subcellular Location:
Secreted.
Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Database links:
Entrez Gene: 345275 Human
Entrez Gene: 243168 Mouse
Entrez Gene: 305150 Rat
Omim: 612127 Human
SwissProt: Q7Z5P4 Human
SwissProt: Q8VCR2 Mouse
SwissProt: Q5M875 Rat
Unigene: 284414 Human
Unigene: 284944 Mouse
Unigene: 25104 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
