Rabbit Anti-SHQ1/FITC Conjugated antibody

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FLJ10539; Protein SHQ1 homolog; shq1; SHQ1 homolog (S. cerevisiae); SHQ1 homolog; SHQ1, H/ACA ribonucleoprotein assembly factor; SHQ1_HUMAN; Shq1p.

Cat:

SL17473R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human SHQ1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

65kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010]

Function:
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.

Subcellular Location:
Cytoplasm > cytosol. Nucleus > nucleoplasm. May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies. Absent from most H/ACA-box RNA transcription sites.

Similarity:
Belongs to the SHQ1 family.
Contains 1 CS domain.

Database links:

Entrez Gene: 55164 Human

Entrez Gene: 72171 Mouse

Omim: 613663 Human

SwissProt: Q6PI26 Human

SwissProt: Q7TMX5 Mouse

Unigene: 606584 Human

Unigene: 256022 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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