background:
LBXCOR1 is a 965 amino acid protein belonging to the SKI family. Localizing to nucleus, LBXCOR1 is highly expressed in the central nervous system (CNS) as well as developing spinal cord and adult brain and testis. LBXCOR1 contains a CH1 domain which is required for transcriptional repression and also acts as a transcriptional co-repressor of LBX1. LBXCOR1 additionally interacts with SMAD1, SMAD2 and SMAD3, and inhibits BMP signaling. Existing as three alternatively spliced isoforms, the gene encoding LBXCOR1 maps to human chromosome 15q23. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and consists of about 3% of the human genome. Angelman and Prader-Willi syndromes, as well as Tay-Sachs disease and Marfan syndorme, are all associated with mutations to chromosome 15.
Function:
Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling.
Subcellular Location:
Nucleus.
Tissue Specificity:
Present specifically in cerebellar Purkinje cells (at protein level).
Similarity:
Belongs to the SKI family.
Database links:
Entrez Gene: 207667 Mouse
Entrez Gene: 315748 Rat
SwissProt: Q8BX46 Mouse
SwissProt: P84551 Rat
Unigene: 36349 Mouse
Unigene: 441440 Mouse
Unigene: 58197 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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