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Home > Product > Antibody > Rabbit Anti-OTUD5/DUBA /FITC Conjugated antibody
Deubiquinating enzyme A; Deubiquitinating enzyme A; DKFZp761A052; DUBA; MGC104871; OTTHUMP00000025821; OTU domain containing 5; OTU domain containing protein 5; OTU domain-containing protein 5; OTUD 5; otud5; OTUD5_HUMAN.
Cat:
SL17566R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,Chicken,Rabbit,)
Immunogen：
KLH conjugated synthetic peptide derived from human OTUD5/DUBA
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
61kDa
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Product PDFs
Datasheet:


background:
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

Function:
Negative regulator of innate immune system. Has deubiquitinating activity that is directed towards 'Lys-63'-linked polyubiquitin chains. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production.

Subunit:
Interacts with TRAF3.

Tissue Specificity:
Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.

Post-translational modifications:
Phosphorylation at Ser-177 is required for deubiquitinating activity.

Similarity:
Belongs to the peptidase C85 family.
Contains 1 OTU domain.

Database links:

Entrez Gene: 55593 Human

Entrez Gene: 54644 Mouse

Entrez Gene: 363452 Rat

Omim: 300713 Human

SwissProt: Q96G74 Human

SwissProt: Q3U2S4 Mouse

SwissProt: Q2YDU3 Rat

Unigene: 496098 Human

Unigene: 142827 Mouse

Unigene: 97794 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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