background:
Reactive oxygen species (ROS) are highly reactive molecules that are a normal consequence of aerobic metabolism. Cellular ROS damage can induce apoptosis and spontaneous mutagenesis. Oxr1 (Oxidation resistance protein 1) is a 758 amino acid mitochondrial protein that is most likely involved in protection from oxidative damage. Oxr1 is highly conserved from yeast to humans and is specific to eukaryotes.Induced by heat and oxidative stress, the carboxyl-terminal half of Oxr1 is required for its function. Upregulation of superoxide dismutase and catalase was observed in developing drosophila mutants that lacked the gene encoding Oxr1, suggesting that oxidative stress may trigger compensatory protein expression. There are four isoforms of Oxr1 that are produced as a result of alternative splicing events.
Function:
May be involved in protection from oxidative damage.
Subcellular Location:
Mitochondrion.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the OXR1 family.
Contains 1 GRAM domain.
Contains 1 LysM repeat.
Contains 1 TLD domain.
Database links:
Entrez Gene: 55074 Human
Entrez Gene: 170719 Mouse
Entrez Gene: 117520 Rat
Omim: 605609 Human
SwissProt: Q8N573 Human
SwissProt: Q4KMM3 Mouse
SwissProt: Q4V8B0 Rat
Unigene: 127286 Human
Unigene: 740427 Human
Unigene: 254267 Mouse
Unigene: 4252 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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