Rabbit Anti-SPCS3/FITC Conjugated antibody

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DKFZp564J1864; FLJ22649; Microsomal signal peptidase 22/23 kDa subunit; Microsomal signal peptidase 23 kDa subunit; PRO3567; Signal peptidase complex subunit 3; Signal peptidase complex subunit 3 homolog (S. cerevisiae); Signal peptidase complex su

Cat:

SL17643R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human SPCS3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

20kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
SPCS3 (signal peptidase complex subunit 3), also known as SPC3, is a 36 amino acid single-pass type II membrane protein that localizes to both the microsome and the endoplasmic reticulum (ER) and belongs to the SPCS (signal peptidase complex subunit) family. Existing as a component of the microsomal signal peptidase complex which consists of five members, SPCS3 functions to remove signal peptides from proteins that are translated to the lumen of the ER. The gene encoding SPCS3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

Function:
A component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.

Subunit:
Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.

Subcellular Location:
Endoplasmic reticulum and Microsome membrane;: Single-pass type II membrane protein

Similarity:
Belongs to the SPCS3 family.

Database links:

Entrez Gene: 767917 Cow

Entrez Gene: 404005 Dog

Entrez Gene: 60559 Human

Entrez Gene: 76219 Mouse

Entrez Gene: 76976 Mouse

Entrez Gene: 10072464 Rat

Entrez Gene: 317409 Rat

SwissProt: Q3SZU5 Cow

SwissProt: P61008 Dog

SwissProt: P61009 Human

SwissProt: Q9D365 Mouse

SwissProt: Q568Z4 Rat