Rabbit Anti-SPIDR/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-SPIDR/FITC Conjugated antibody

DNA repair-scaffolding protein; KIAA0146; Scaffolding protein involved in DNA repair; SPIDR; SPIDR_HUMAN.

Cat:

SL17664R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human SPIDR

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

100kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.

Function:
Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.

Subunit:
Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts (via SLCterminal region) with BLM; the interaction is direct. Interacts with RAD51; the interaction is direct. Interacts (via the SLCterminal region) with FIGNL1 (via N-terminal one-half region);the interaction is direct.

Subcellular Location:
Nucleus. Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment.

Database links:

Entrez Gene: 23514 Human

Omim: 615384 Human

SwissProt: Q14159 Human

Unigene: 381058 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall