Rabbit Anti-MMP6/MPHOSPH6/FITC Conjugated antibody

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M phase phosphoprotein 6; M phase phosphoprotein 6 variant; M-phase phosphoprotein 6; MT-MMP-6; MMP 6; MMP; MPH6_HUMAN; MPHOSH6; MPHOSPH 6; Mphosph6; MPP 6; MPP; MPP6.

Cat:

SL17687R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human MMP6

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

19kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The matrix metalloproteinases (MMPs) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. MMP catalysis requires both calcium and zinc. Membrane-type matrix metalloproteinases are type I membrane proteins that function to activate other MMPs. MT-MMP activation appears to be mediated by members of the proprotein convertase family, suggesting that a proprotein convertase/MT-MMP/MMP cascade may be involved in the regulation of ECM turnover. MT-MMP-6 (also known as MMP-25, MT6-MMP or Leukolysin) is the second GPI-anchored proteinase in the MMP family. Similar to MMP-3, MT-MMP-6 is able to cleave type IV collagen, Fibronectin, fibrin and gelatin. However, MT-MMP-6 cannot cleave Laminin-1 or activate progelatinase B. MT-MMP 6 is expressed in leukocytes, lung and spleen

Function:
RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.

Subunit:
Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10 and SKIV2L2.

Subcellular Location:
Nucleus > nucleolus. Cytoplasm. Cytoplasmic in M phase.

Post-translational modifications:
Phosphorylated in M (mitotic) phase.

Similarity:
Belongs to the MPP6 family.

Database links:

Entrez Gene: 10200 Human

Entrez Gene: 68533 Mouse

Omim: 605500 Human

SwissProt: Q99547 Human

SwissProt: Q9D1Q1 Mouse

Unigene: 34880 Human

Unigene: 181836 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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