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Rabbit Anti-MOB4A/FITC Conjugated antibody
background:
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Function:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.
Similarity:
Belongs to the MOB1/phocein family.
Database links:
Entrez Gene: 92597 Human
Entrez Gene: 68473 Mouse
Omim: 609282 Human
SwissProt: Q7L9L4 Human
SwissProt: Q8BPB0 Mouse
Unigene: 691454 Human
Unigene: 700445 Human
Unigene: 730274 Human
Unigene: 35764 Mouse
Unigene: 392493 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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