background:
This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012]
Function:
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Subcellular Location:
Expressed in the brain.
Tissue Specificity:
Expressed in the brain.
Database links:
Entrez Gene: 216858 Human
Entrez Gene: 76719 Mouse
SwissProt: Q7Z3B3 Human
SwissProt: Q80TG1 Mouse
Unigene: 648744 Human
Unigene: 136418 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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