Rabbit Anti-MTF2/FITC Conjugated antibody

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DJ976O13.2; hPCl2; M96; metal regulatory transcription factor 2; Metal response element binding transcription factor 2; metal-response element DNA-binding protein M96; PCL2; MTF2_HUMAN; polycomb-like 2; polycomb-like protein 2; Putative DNA bindi

Cat:

SL17872R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human MTF2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

67kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Binds to the metal-regulating-element (MRE) of metallothionein gene promoter. May be involved in the activation of MT (metallothionein) genes in response to heavy-metal ions.

Function:
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

Subunit:
Associated component of the PRC2 complex (By similarity).

Subcellular Location:
Nuclear

Similarity:
Belongs to the Polycomblike family.
Contains 2 PHD-type zinc fingers.
Contains 1 Tudor domain.

Database links:

Entrez Gene: 22823 Human

Entrez Gene: 17765 Mouse

Entrez Gene: 72905 Rat

Omim: 609882 Human

SwissProt: Q9Y483 Human

SwissProt: Q02395 Mouse

Unigene: 229278 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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