Rabbit Anti-MTG1/GTPBP7/FITC Conjugated antibody

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GTP; GTP binding protein; GTP binding protein 7 (putative); GTP binding protein 7; GTP-binding protein 7 (putative); GTP-binding protein 7; GTPBP7; Mitochondrial GTPase 1; mitochondrial GTPase 1 homolog (S. cerevisiae); MTG1; MTG1_HUMAN; OTTHUM

Cat:

SL17874R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human MTG1/GTPBP7

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

37kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
MTH1 is a 179 amino acid cytoplasmic protein that is a member of the nudix hydrolase family. Highly expressed in testis, thymus and proliferating blood lymphocytes, MTH1 functions as an antimutagenic that hydrolyzes oxidized purine nucleoside triphosphates to their corresponding monophosphates. Through its ability to enzymatically hydrolyze ATP and GTP to AMP and GMP, respectively, MTH1 prevents misincorporation of GTP into DNA, thus preventing A:T to C:G transversions. The cytoplasmic location of MTH1, along with its antimutagenic capabilities, suggests that it may also be involved in the sanitization of nucleotide pools for both mitochondrial and nuclear genomes. Four isoforms of MTH1 exist—three of which are formed due to alternative splicing events and one of which is formed via a single-nucleotide polymorphism. Overexpression of MTH1 is implicated in prostate and cell lung carcinomas

Function:
Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit.

Subcellular Location:
Mitochondrion.

Similarity:
Belongs to the MMR1/HSR1 GTP-binding protein family. MTG1 subfamily.
Contains 1 G (guanine nucleotide-binding) domain.

Database links:

Entrez Gene: 92170 Human

Entrez Gene: 509768 Cow

Entrez Gene: 212508 Mouse

SwissProt: Q4PS77 Cow

SwissProt: Q9BT17 Human

SwissProt: Q8R2R6 Mouse

Unigene: 501578 Human

Unigene: 296088 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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