background:
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
Subcellular Location:
Cytoplasm. Membrane. Localized to perinuclear region.
Tissue Specificity:
Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow.
Similarity:
Belongs to the protein-tyrosine phosphatase family.
Non-receptor class myotubularin subfamily.
Contains 1 FYVE-type zinc finger.
Contains 1 myotubularin phosphatase domain.
Database links:
Entrez Gene: 782743 Cow
Entrez Gene: 9110 Human
Entrez Gene: 170749 Mouse
Entrez Gene: 287607 Rat
Omim: 603559 Human
SwissProt: Q9NYA4 Human
SwissProt: Q91XS1 Mouse
Unigene: 514373 Human
Unigene: 399376 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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