background:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Function:
Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1 (67), CK2 (65.5), CK3 (64), CK4 (59), CK5 (58), CK6 (56), CK7 (54), CK8 (52.5) and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10 (56.5), CK12 (56), CK13 (53), CK14 (50), CK16( 48), CK17 (46), CK18 (45), CK19(48) and CK20(46).
Subunit:
Heterotetramer of two type I and two type II keratins.disulfide-linked keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins.
Subcellular Location:
Cytoplasmic
Similarity:
Belongs to the intermediate filament family.
Database links:
Entrez Gene: 408039 Chicken
Entrez Gene: 408040 Chicken
Entrez Gene: 507464 Cow
Entrez Gene: 3860 Human
Entrez Gene: 3861 Human
Entrez Gene: 3866 Human
Entrez Gene: 3868 Human
Entrez Gene: 16663 Mouse
Entrez Gene: 16664 Mouse
Entrez Gene: 16665 Mouse
Entrez Gene: 16666 Mouse
Entrez Gene: 287699 Rat
Entrez Gene: 287700 Rat
Entrez Gene: 287701 Rat
Entrez Gene: 303530 Rat
Omim: 29630 Human
Omim: 29665 Human
Omim: 29666 Human
Omim: 29667 Human
SwissProt: Q6PVZ1 Chicken
SwissProt: Q17QL7 Cow
SwissProt: P02533 Human
SwissProt: P08779 Human
SwissProt: P13646 Human
SwissProt: P19012 Human
SwissProt: P08730 Mouse
SwissProt: Q61414 Mouse
SwissProt: Q61781 Mouse
SwissProt: Q9Z2K1 Mouse
SwissProt: Q6IFV1 Rat
SwissProt: Q6IFV3 Rat
SwissProt: Q6IFV4 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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