Rabbit Anti-HVCN1/FITC Conjugated antibody

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HV 1; HV1; HVCN 1; HVCN1; HVCN1_HUMAN; Hydrogen voltage gated channel 1; Hydrogen voltage-gated channel 1; Voltage gated hydrogen channel 1; Voltage sensor domain only protein; Voltage sensor domain-only protein; Voltage-gated hydrogen channel 1

Cat:

SL18109R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human HVCN1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

32kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Function:
Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.

Subcellular Location:
Membrane.

Tissue Specificity:
Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.

Similarity:
Belongs to the hydrogen channel family.

Database links:

Entrez Gene: 84329 Human

Entrez Gene: 74096 Mouse

Omim: 611227 Human

SwissProt: Q96D96 Human

SwissProt: Q3U2S8 Mouse

Unigene: 211511 Human

Unigene: 334637 Human

Unigene: 21764 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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