background:
ARHGAP36 is a 547 amino acid protein that contains one Rho-GAP domain. Conserved in chimpanzee, dog, cow, mouse and rat, ARHGAP36 exists as five alternatively spliced isoforms and is encoded by a gene that maps to human chromosome Xq26.1. Chromosome X consists of nearly 153 million base pairs encoding approximately 1,000 genes. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are X chromosome-linked conditions that affect males more frequently because males carry a single X chromosome.
Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Similarity:
Contains 1 Rho-GAP domain.
Database links:
Entrez Gene: 158763 Human
SwissProt: Q6ZRI8 Human
Unigene: 22905 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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