Rabbit Anti-Intrinsic Factor/FITC Conjugated antibody

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Gastric Intrinsic Factor; Gastric intrinsic factor (vitamin B synthesis); GIF; IF; IFMH; INF; Intrinsic factor; TCM3; TCN3.

Cat:

SL18173R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human Intrinsic Factor

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

43kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]

Function:
Intrinsic factor promotes absorption of the essential vitamin Cobalamin (Cbl) in the ileum by specific receptor mediated endocytosis. Defects in the gene GIF are the cause of hereditary intrinsic factor deficiency (IFD) also called congenital pernicious anemia. IFD is an autosomal recessive disorder characterized by megaloblastic anemia.

Subcellular Location:
Secreted

Tissue Specificity:
Gastric mucosa.

DISEASE:
Hereditary intrinsic factor deficiency (IFD)

Similarity:
Belongs to the eukaryotic cobalamin transport proteinsfamily.

Database links:

Entrez Gene: 2694 Human

Entrez Gene: 1923 Mouse

Entrez Gene: 29319 Rat

Omim: 609342 Human

SwissProt: P27352 Human

SwissProt: P52787 Mouse

SwissProt: P17267 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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