Rabbit Anti-MYL2/FITC Conjugated antibody

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Cardiac myosin light chain-2; Cardiac ventricular myosin light chain 2; CMH10; MLC 2v; MLC-2; MLC-2v; MLC2; MLRV_HUMAN; MYL 2; MYL2; Myosin light chain 2 regulatory cardiac slow; Myosin light polypeptide 2 regulatory cardiac slow; Myosin regul

Cat:

SL18248R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Chicken,Pig,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Cardiac ventricular myosin light chain 2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

20kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Function:
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.

Subunit:
Myosin is a hexamer of 2 heavy chains and 4 light chains.

Tissue Specificity:
Expressed in fetal and adult skeletal muscle.

Post-translational modifications:
N-terminus is methylated by METTL11A/NTM1.

DISEASE:
Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.

Similarity:
Contains 3 EF-hand domains.

Database links:

Entrez Gene: 505519 Cow

Entrez Gene: 403614 Dog

Entrez Gene: 4633 Human

Entrez Gene: 17906 Mouse

Entrez Gene: 363925 Rat

Omim: 160781 Human

SwissProt: Q3SZE5 Cow

SwissProt: P10916 Human

SwissProt: P51667 Mouse

SwissProt: P08733 Rat

Unigene: 48942 Cow

Unigene: 75535 Human

Unigene: 1529 Mouse

Unigene: 37176 Rat

Unigene: 6534 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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