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Rabbit Anti-CES1/Liver Carboxylesterase 1/FITC Conjugated antibody
background:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
Subcellular Location:
Endoplasmic reticulum lumen.
Tissue Specificity:
Expressed predominantly in liver with lower levels in heart and lung.
Post-translational modifications:
Contains sialic acid.
Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.
Similarity:
Belongs to the type-B carboxylesterase/lipase family.
Database links:
Entrez Gene: 1066 Human
Entrez Gene: 12623 Mouse
Entrez Gene: 24346 Rat
Entrez Gene: 29225 Rat
Omim: 114835 Human
SwissProt: P23141 Human
SwissProt: Q8VCC2 Mouse
SwissProt: P10959 Rat
SwissProt: Q63108 Rat
Unigene: 558865 Human
Unigene: 22720 Mouse
Unigene: 2549 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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