background:
Lectin mannose-binding 1, also designated vesicular integral-membrane protein (VIP36), and lectin mannose-binding 2, also designated ERGISLC53, comprise a family of membrane bound, ubiquitously expressed proteins involved in the selective transport of newly synthesized glycoproteins from the endoplasmic reticulum to the ER-Golgi intermediate compartment. VIPL (VIP36-like protein), also known as LMAN2L (lectin, mannose-binding 2-like), is a 348 amino acid single-pass type I membrane protein that localizes to the endoplasmic reticulum and Golgi apparatus. Containing one L-type lectin-like domain, VIPL is highly expressed in skeletal muscle and kidney, and is found at intermediate levels in heart, liver and placenta, and low levels in brain, thymus, spleen, small intestine and lung. VIPL is suggested to be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. VIPL may function as a regulator of ERGISLC53. VIPL exists a two alternatively spliced isoforms.
Function:
May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGISLC53.
Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
Tissue Specificity:
Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.
Similarity:
Contains 1 L-type lectin-like domain.
Database links:
Entrez Gene: 81562 Human
Entrez Gene: 214895 Mouse
Entrez Gene: 301343 Rat
Omim: 609552 Human
SwissProt: Q9H0V9 Human
SwissProt: P59481 Mouse
Unigene: 655743 Human
Unigene: 287854 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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