background:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Subcellular Location:
Cell membrane.
Post-translational modifications:
Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
Similarity:
Belongs to the G-protein coupled receptor 2 family.
LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 olfactomedin-like domain.
Contains 1 SUEL-type lectin domain.
Database links:
Entrez Gene: 23284 Human
Entrez Gene: 319387 Mouse
Entrez Gene: 170641 Rat
SwissProt: Q9HAR2 Human
SwissProt: Q80TS3 Mouse
SwissProt: Q9Z173 Rat
Unigene: 28391 Human
Unigene: 570770 Human
Unigene: 273631 Mouse
Unigene: 461016 Mouse
Unigene: 203386 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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