Rabbit Anti-LRRC17/FITC Conjugated antibody

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37 kDa leucine rich repeat (LRR) protein; 37kDa; 4833425M04Rik; 6130400C22Rik; Leucine-rich repeat-containing protein 17; LRC17_HUMAN; LRRC17; p37NB; UNQ3076/PRO9909.

Cat:

SL18368R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human LRRC17

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

50kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
LRRC17 is a 441 amino acid protein that localizes to the cytoplasm and contains six LRR repeats. The protein is expressed at high levels in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung. LRRC17 is expressed at higher levels in non-neuronal (S-type) neuroblastoma cells than in neuroblastic (N-type) neuroblastoma cells.

Function:
Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors.

Subcellular Location:
Secreted; extracellular space.

Tissue Specificity:
Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells.

Similarity:
Contains 6 LRR (leucine-rich) repeats.
Contains 2 LRRCT domains.
Contains 1 LRRNT domain.

Database links:

Entrez Gene: 10234 Human

Entrez Gene: 777690 Cow

Entrez Gene: 100050177 Horse

Entrez Gene: 74511 Mouse

Entrez Gene: 100737774 Pig

Entrez Gene: 100340395 Rabbit

Entrez Gene: 502715 Rat

SwissProt: Q8N6Y2 Human

SwissProt: Q9CXD9 Mouse

Unigene: 567412 Human

Unigene: 439963 Mouse

Unigene: 207235 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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