background:
LRRC33 is a 692 amino acid protein that contains 17 LRR repeats. The gene encoding LRRC33 maps to chromosome 3, which encodes over 1,100 genes. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Marfan syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
Function:
Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex.
May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.
Subunit:
Interacts with CYBB/NOX2; the interaction is direct By similarity. Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors.
Subcellular Location:
Membrane; Single pass type I membrane protein.
Tissue Specificity:
Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen.
Similarity:
Contains 21 LRR (leucine-rich) repeats.
Database links:
Entrez Gene: 375387 Human
Entrez Gene: 224109 Mouse
Entrez Gene: 303875 Rat
SwissProt: Q86YC3 Human
SwissProt: Q8BMT4 Mouse
SwissProt: Q5BK65 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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