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Rabbit Anti-LSM14A/C19orf13/FITC Conjugated antibody
background:
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]
Function:
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.
Subunit:
Component of a ribonucleoprotein (RNP) complex.
Subcellular Location:
Cytoplasm. Cytoplasm > P-body. Targeted to stress granules (SGs) in response to cellular stress.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the LSM14 family.
Contains 1 DFDF domain.
Database links:
Entrez Gene: 26065 Human
Entrez Gene: 67070 Mouse
Entrez Gene: 361554 Rat
Omim: 610677 Human
SwissProt: Q8ND56 Human
SwissProt: Q8K2F8 Mouse
Unigene: 407368 Human
Unigene: 276503 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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