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Rabbit Anti-LXR beta/FITC Conjugated antibody
background:
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 36245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
Function:
Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
Subunit:
Forms a heterodimer with RXR.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the nuclear hormone receptor family.
NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links:
Entrez Gene: 7376 Human
Entrez Gene: 58851 Rat
Omim: 600380 Human
SwissProt: P55055 Human
SwissProt: Q62755 Rat
Unigene: 432976 Human
Unigene: 786 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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