Rabbit Anti-LYAR/FITC Conjugated antibody

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Cell growth regulating nucleolar protein; Cell growth-regulating nucleolar protein; Likely ortholog of mouse Ly1; reactive clone; Ly1; reactive; Ly1; reactive homolog (mouse); Ly1; reactive homolog; LYAR; LYAR_HUMAN; ZC2HC2; ZLYAR.

Cat:

SL18456R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human LYAR

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

44kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
LYAR is a 379 amino acid nucleolar protein containing two C2HSLCtype zinc fingers. Expressed at high levels in immature spermatocytes, early embryos and in fetal liver and thymus with low expression in kidney and spleen, LYAR may function as a novel nucleolar oncoprotein to regulate cell growth. It is suggested that LYAR participates in regulating the stability of C23, a protein that is critical for maintaining the self-renewal and differentiation of embryonic stem cells (ESCs). C23 is a eukaryotic nucleolar phosphoprotein that influences synthesis and maturation of ribosomes. LYAR forms a complex with C23, thereby preventing self-cleavage and maintaining steady levels of C23 in undifferentiated ESCs. Downregulation of LYAR decreases C23 stability in ESCs, which in turn negatively affects growth and increases the rate of apoptosis of these cells.

Subcellular Location:
Nucleus

Similarity:
Contains 2 C2HSLCtype zinc fingers.

Database links:

Entrez Gene: 55646 Human

Entrez Gene: 17089 Mouse

Entrez Gene: 289707 Rat

SwissProt: Q9NX58 Human

SwissProt: Q08288 Mouse

SwissProt: Q6AYK5 Rat

Unigene: 425427 Human

Unigene: 28560 Mouse

Unigene: 137862 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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