background:
The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Function:
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.
Subcellular Location:
Membrane.
Post-translational modifications:
Autopalmitoylated.
DISEASE:
Defects in ZDHHC15 are the cause of mental retardation X-linked type 91 (MRX91) [MIM:300577]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
Similarity:
Belongs to the DHHC palmitoyltransferase family.
Contains 1 DHHSLCtype zinc finger.
Database links:
Entrez Gene: 158866 Human
Omim: 300576 Human
SwissProt: Q96MV8 Human
Unigene: 253211 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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