Rabbit Anti-ZDHHC2/ZNF372/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-ZDHHC2/ZNF372/FITC Conjugated antibody

DHHC-2; Palmitoyltransferase ZDHHC2; Ream; Rec; Reduced expression associated with metastasis protein; Reduced expression in cancer protein; ZDHC2_HUMAN; Zdhhc2; Zinc finger DHHC domain-containing protein 2; Zinc finger protein 372; ZNF372.

Cat:

SL1896R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Chicken,Dog,Pig,Horse,Rabbit,Monkey,)

Immunogen：

KLH conjugated synthetic peptide derived from human ZDHHC2/ZNF372

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

42kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
ZDHHC2 is a 367 amino acid multi-pass membrane protein that contains one DHHSLCtype zinc finger. The ubiquitously expressed ZDHHC2 protein functions as a palmitoyltransferase that uses palmitoyl-CoA and catalyzes the conversion of target proteins, namely GAP-43 and PSD-95, to S-palmitoyl proteins. Defects in the gene encoding ZDHHC2 are found in colorectal cancer and hepatocellular carcinoma, suggesting a role for ZDHHC2 in tumorigenesis. The gene encoding human ZDHHC2 maps to chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Function:
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.

Subcellular Location:
Membrane.

Tissue Specificity:
Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.

DISEASE:
Note=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.

Similarity:
Belongs to the DHHC palmitoyltransferase family.
Contains 1 DHHSLCtype zinc finger.

Database links:

Entrez Gene: 51201 Human

Entrez Gene: 70546 Mouse

Entrez Gene: 246326 Rat

SwissProt: Q9UIJ5 Human

SwissProt: P59267 Mouse

Unigene: 726197 Human

Unigene: 34326 Mouse

Unigene: 17310 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall