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Rabbit Anti-ZNF289/ARFGAP2/FITC Conjugated antibody
background:
ZNF289 functions as a GTPase-activating protein (GAP) for ARF family proteins. Localizing to the cytoplasmic side of the Golgi apparatus, ZNF289 contains one ARF-GAP domain and is found associated with COP-I-coated vesicles.
Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.
Subunit:
Interacts with the coatomer complex. Interacts with the SLCterminal appendage domain of COPG1.
Subcellular Location:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note: Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Similarity:
Contains 1 Arf-GAP domain.
Database links:
Entrez Gene: 84364 Human
Entrez Gene: 505438 Cow
Entrez Gene: 77038 Mouse
Entrez Gene: 362162 Rat
Omim: 606908 Human
SwissProt: A1L520 Cow
SwissProt: Q8N6H7 Human
SwissProt: Q99K28 Mouse
SwissProt: Q3MID3 Rat
Unigene: 436204 Human
Unigene: 43636 Mouse
Unigene: 3707 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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