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Rabbit Anti-phospho-LYRIC (Ser568)/FITC Conjugated antibody
background:
LYRIC is a type II membrane protein, the precise role of which has yet to be defined. It is expressed in breast and prostate carcinoma and is a potential mediator of lung metastasis. It has also been found in mouse Purkinje neurons and cerebellum. In epithelial cells it is recruited to tight junctions (TJ) during the maturation of the TJ complexes. LYRIC co-localizes with beta-catenin in normal and tumour tissues.
Function:
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Subunit:
Interacts with BCCIP, CREBBP/CBP and RELA/p65.
Subcellular Location:
Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
Database links:
Entrez Gene: 92140 Human
Entrez Gene: 509788 Cow
Entrez Gene: 67154 Mouse
Entrez Gene: 170910 Rat
Omim: 610323 Human
SwissProt: Q86UE4 Human
SwissProt: Q80WJ7 Mouse
SwissProt: Q9Z1W6 Rat
Unigene: 377155 Human
Unigene: 130883 Mouse
Unigene: 6864 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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