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Home > Product > Antibody > Rabbit Anti-MAFG/FITC Conjugated antibody
AA545192; Basic leucine zipper transcription factor MafG; C630022N07Rik; hMAF; MAFG; MAFG v maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian); MAFG_HUMAN; MGC13090; MGC20149; RP23 84C12.9; Transcription factor MafG; V maf musculoap
Cat:
SL18615R-FITC
Species Reactivity：
Human,(predicted: Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human MAFG
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
18kDa
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Price: $
Product PDFs
Datasheet:


background:
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

Function:
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+).

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in skeletal muscle. Also expressed in heart and brain.

Post-translational modifications:
Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
Sumoylation at Lys-14 is required for active transcriptional repression.

Similarity:
Belongs to the bZIP family. Maf subfamily.
Contains 1 bZIP domain.

Database links:

Entrez Gene: 4097 Human

Entrez Gene: 17134 Mouse

Entrez Gene: 64188 Rat

Omim: 602020 Human

SwissProt: O15525 Human

SwissProt: O54790 Mouse

SwissProt: Q76MX4 Rat

Unigene: 252229 Human

Unigene: 53610 Mouse

Unigene: 292957 Mouse

Unigene: 393664 Mouse

Unigene: 17361 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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