background:
MAMSTR is a 415 amino acid nuclear protein that functions as a transcriptional coactivator by stimulating MEF-2. Containing one SAP domain, MAMSTR is expressed in spleen, placenta, skeletal muscle and brain, and exists as three alternatively spliced isoforms. The gene encoding MAMSTR maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs).
Function:
Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in skeletal muscle, brain, placenta and spleen.
Similarity:
Contains 1 SAP domain.
Database links:
Entrez Gene: 284358 Human
Omim: 610349 Human
SwissProt: Q6ZN01 Human
Unigene: 191815 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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