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Rabbit Anti-MAP3K12/ZPK/FITC Conjugated antibody
background:
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Function:
May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
Subcellular Location:
Cytoplasm. Membrane.
Tissue Specificity:
Highly expressed in brain and kidney.
Post-translational modifications:
Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated.
Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family.
MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 7786 Human
Entrez Gene: 21284 Mouse
Omim: 600447 Human
SwissProt: Q12852 Human
SwissProt: Q60700 Mouse
Unigene: 713539 Human
Unigene: 172897 Mouse
Unigene: 236513 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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