Home
>
Product
>
Antibody
>
Rabbit Anti-MCAF2/FITC Conjugated antibody
background:
MCAF2 is a 682 amino acid nuclear protein that exists as two alternatively spliced isoforms. MCAF2 can act as either an activator or repressor, thereby modulating chromatin formation and/or transcription regulation by linking transcription factors to transcription apparatuses. A member of the MCAF family, MCAF2 contains one fibronectin type-III domain and is thought to form a complex with ESET and MBD1. The gene encoding MCAF2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Function:
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity
Subunit:
Interacts with MBD1, SETDB1 and SP1. Probably forms a complex with SETDB1 and MBD1.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the MCAF family.
Contains 1 fibronectin type-III domain.
Database links:
Entrez Gene: 80063 Human
Entrez Gene: 75329 Mouse
Omim: 613645 Human
SwissProt: Q5U623 Human
SwissProt: Q3UL97 Mouse
Unigene: 513343 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|