Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Mediator complex subunit 6 family.
Database links:
Entrez Gene: 10001 Human
Entrez Gene: 426282 Chicken
Entrez Gene: 505293 Cow
Entrez Gene: 69792 Mouse
Entrez Gene: 29936 Rat
Omim: 602984 Human
SwissProt: Q3SZY9 Cow
SwissProt: O75586 Human
SwissProt: Q921D4 Mouse
Unigene: 497353 Human
Unigene: 279993 Mouse
Unigene: 97814 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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