background:
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Mediator complex subunit 4 family.
Database links:
Entrez Gene: 29079 Human
Entrez Gene: 418859 Chicken
Entrez Gene: 515299 Cow
Entrez Gene: 67381 Mouse
Entrez Gene: 306030 Rat
Entrez Gene: 550582 Zebrafish
Omim: 605718 Human
SwissProt: Q3SYZ9 Cow
SwissProt: Q9NPJ6 Human
SwissProt: Q3UL96 Mouse
SwissProt: Q8BVG6 Mouse
SwissProt: Q9CQA5 Mouse
SwissProt: Q561Q8 Rat
SwissProt: Q561X3 Zebrafish
Unigene: 181112 Human
Unigene: 282888 Mouse
Unigene: 114469 Rat
Unigene: 84720 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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