background:
This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Mediator complex subunit 8 family.
Database links:
Entrez Gene: 112950 Human
Entrez Gene: 80509 Mouse
Entrez Gene: 362575 Rat
Entrez Gene: 404615 Zebrafish
Omim: 607956 Human
SwissProt: Q96G25 Human
SwissProt: Q9D7W5 Mouse
SwissProt: Q6NYT1 Zebrafish
Unigene: 301756 Human
Unigene: 259567 Mouse
Unigene: 229078 Rat
Unigene: 84281 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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