background:
EGFL3 (epidermal growth factor-like protein 3), also known as MEGF6 (multiple epidermal growth factor-like domains protein 6), is a 1,541 amino acid secreted protein containing twenty-seven EGF-like domains and an EMI domain. Existing as two alternatively spliced isoforms, the gene encoding EGFL3 maps to human chromosome 1p36.32. The largest human chromosome, spanning about 260 million base pairs and making up 8% of the human genome, chromosome 1 contains about 3,000 genes. The rare aging disease Hutchinson-Gilford progeria, as well as Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome, are associated with chromosome 1.
Subcellular Location:
Secreted
Similarity:
Contains 27 EGF-like domains.
Contains 1 EMI domain.
Database links:
Entrez Gene: 1953 Human
Entrez Gene: 230971 Mouse
Entrez Gene: 65049 Rat
Omim: 604266 Human
SwissProt: O75095 Human
SwissProt: Q80V70 Mouse
SwissProt: O88281 Rat
Unigene: 593645 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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