Function:
Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.
Subunit:
Interacts with ALKSH6. Interacts with ASPSCR1 and UBXN6; interaction with ASPSCR1, but not with UBXN6, enhances VCP methylation.
Subcellular Location:
Cytoplasm
Similarity:
Belongs to the methyltransferase superfamily. METTL21 family.
Database links:
Entrez Gene: 79609 Human
Entrez Gene: 207965 Mouse
Entrez Gene: 362748 Rat
Omim: 615260 Human
SwissProt: Q9H867 Human
SwissProt: Q8C436 Mouse
Unigene: 558541 Human
Unigene: 102487 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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