Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
Subunit:
Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with USFT.
Subcellular Location:
Nucleus.
Database links:
Entrez Gene: 54700 Human
Entrez Gene: 106298 Mouse
Entrez Gene: 100173945 Orangutan
Omim: 605121 Human
SwissProt: Q9NYV6 Human
SwissProt: B2RS91 Mouse
SwissProt: Q5R4N9 Orangutan
Unigene: 92078 Human
Unigene: 288606 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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