Rabbit Anti-RREB1/FITC Conjugated antibody

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FINB; Finger protein in nuclear bodies; Hindsight homolog; HNT; LZ321; Raf responsive zinc finger protein LZ321; Raf-responsive zinc finger protein LZ321; RAS responsive element binding protein 1; Ras-responsive element-binding protein 1; RREB 1;

Cat:

SL18856R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Chicken,Dog,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human RREB1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

181kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Function:
Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.

Subcellular Location:
Nucleus speckle.

Tissue Specificity:
Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 15 C2H2-type zinc fingers.

Database links:

Entrez Gene: 6239 Human

Entrez Gene: 68750 Mouse

Omim: 602209 Human

SwissProt: Q92766 Human

SwissProt: Q3UH06 Mouse

Unigene: 298248 Human

Unigene: 132634 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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